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副作用》是由裘德·洛,鲁妮·玛拉,查宁·塔图姆,凯瑟琳·泽塔-琼斯,凡妮莎·肖,马琳·爱尔兰,波利·德雷珀,哈拉尔多·阿尔瓦雷斯,詹姆斯·马丁内斯,大卫·科斯塔贝尔,麦米·古默,玛瑞安娜·克拉瓦诺,斯科特· 谢泼德,迈克尔·内森森等主演，四年前，丈夫Martin（查宁·塔图姆 Channing Tatum 饰）的入狱让Emily（鲁妮·玛拉 Rooney Mara 饰）陷入了忧郁之中。如今Martin出狱了，Emily的忧郁并没有减少，反而企图在停车场开车自杀。自杀未遂后，医生Jon（裘德·洛 Jude Law 饰）开始对她进行治疗。Jon了解到Emily以前的医生是Siebert，便找Siebert了解了一些情况。Jon给Emily开了几种治忧郁症的药，似乎都没作用。Emily提出让她服用一种叫Ablixa的药，是她的同事Julia向她推荐的。服用了这种新药之后，Emily病情有所好转，却开始梦游。Jon告诉她，梦游是服用这种药的副作用。一天晚上，Martin回到家中，发现Emily在厨房梦游，Emily更拿着刀刺中了Martin。Martin死亡，法院判处Emily无罪，但她必须...
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