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爱情与灵药》是由安妮·海瑟薇,杰克·吉伦哈尔,朱迪·格雷尔,汉克·阿扎利亚,乔什·加德,奥利弗·普莱特,盖布瑞·马赫特,乔治·席格,吉尔·克雷伯格,凯特·詹宁斯·格兰特,凯瑟琳·温妮克,梅根·弗格森,康斯坦斯·布伦尼曼,娜塔莉·戈尔德,迈克尔·切鲁斯,杰米·亚历山大等主演，杰米（杰克?吉伦哈尔 Jake Gyllenhaal 饰）出身医药世家，舌灿莲花，热情似火，是电器行的金牌销售，不过由于桃花运太壮，以至于因为跟女同事在工作时间亲热，被老板开除。此后，他在辉瑞公司连番洗脑后，成为了一名医药销售代表。为了能打开区域市场，他摸清了某医院的底细，决定从主治医师斯坦下手。他用1千美元的支票，换取了一个实习生的身份，穿梭于诊室。某日，他偶然间邂逅了因帕金森症就诊的女患者玛姬（安妮?海瑟薇 Anne Hathaway 饰），并阴差阳错瞥见了她的乳房。正当花花公子以为占了便宜时，却被玛姬抡包打伤，甚至还拍了照片。为了讨回声誉，他利用关系要到了对方号码，并约她面谈。没想到这次约会，却让两人陷入了匪夷所思的亲密关系之中，令他难以自拔。正当杰米因伟哥成为销售红人时，玛姬的病患却每况愈下……
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